is gabapentin safe for cats with kidney disease

The 20 mg/kg stress-reduction dose of gabapentin may be beneficial to facilitate preventive veterinary care in younger, healthy cats, but this dose may be inappropriate for elderly cats, specifically those with chronic kidney disease (CKD).

A mosaic of treatment

Dr. According to Vanden, between 2% and 20% of all cats and 30% to 40% of cats over the age of 2010 have chronic kidney disease. Recent developments in medical management and diagnostics allow vets to treat some cats for longer periods of time.

“Considering that some of these cats may require treatment for up to three years, we really need to be very thoughtful about what we do and approach our treatment and diagnostics with an evidence-based approach,” the speaker stated.

Imaging tests, the detection of persistent azotemia, or an increase in the serum concentration of symmetric dimethylarginine are typically used to diagnose chronic kidney disease. Staging in accordance with the International Renal Interest Society’s system is the next step.

RenalTech, a new artificial intelligence-based predictive diagnostic tool from Antech Diagnostics, forecast that 12-year-old male cat Billy (above right) would develop chronic kidney disease in the next two years, and that 7-year-old female cat Amber (above left) would not. (Photos courtesy of Antech Diagnostics).

Sophie did not pass away from chronic kidney disease until she was 19 years old. She belonged to Dr. Jessica Quimby is a researcher on chronic kidney disease (CKD) in cats and an associate professor of small animal internal medicine at The Ohio State University College of Veterinary Medicine. (Courtesy of Dr. Quimby).

Based on serum creatinine and SDMA concentrations—the latter of which was added recently—the IRIS stages, which range from 1-4 Additionally, the staging system allows for substaging based on the degree of hypertension and proteinuria.

“Staging becomes crucial because it serves as a means of conveying our current diagnostic and therapeutic status as well as the animal’s expected course and symptomatology,” Dr. Vaden said.

If the veterinarian can determine that the cat’s condition is treatable, it is crucial to find and address any underlying primary renal disease in stages 1 or early 2. For a cat in stages three or late stages two, Dr. Vaden starts evaluating and managing factors inherently associated with progression. For a cat in stage 4, Dr. Vaden diagnoses and manages the various consequences of long-term kidney disease.

“I view the treatment of chronic kidney disease as a mosaic,” said Dr. Vaden said. Rather than providing a one-size-fits-all solution, I attempt to determine which issues are present before addressing those And some of these problems are interrelated. Thus, once more, attempting to view those as a mosaic and determining what needs to be addressed and what can be done to improve the wellbeing of an animal ”.

Dr. Vaden provided advice on managing gastrointestinal symptoms, proteinuria, hypertension, anemia, metabolic acidosis, renal secondary mineral disorders, and hypokalemia (see sidebar).

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Risk factors, predictive diagnostics

A Feb. An analysis of “Risk factors associated with the development of chronic kidney disease in cats evaluated at primary care veterinary hospitals” was published in a 2014 scientific paper published in JAVMA. The study examined feline patients examined at Banfield Pet Hospitals in 2010 using a retrospective case-control methodology.

The abstract states: “Being a neutered male (as opposed to a spayed female), living anywhere in the United States other than the northeast, anesthesia or documented dehydration in the previous year, and thin body condition were risk factors for CKD in cats.” The likelihood of chronic kidney disease (CKD) rose when vomiting, polyuria or polydipsia, appetite or energy loss, or halitosis was present at the time of diagnosis or inclusion in the control group but did not increase when those signs were reported six to twelve months earlier. The probability of CKD decreased with increasing body weight in nondehydrated cats, domestic shorthair breed, and prior diagnosis of diabetes mellitus. The average amount of weight lost in the six to twelve months prior was 10 8% and 2. 1% in cats with and without CKD, respectively. ”.

Dr. Speaking at the AVMA Virtual Convention 2020, Jennifer Ogeer, vice president of medical affairs and commercial marketing at Antech, discussed “Taking the Surprise out of Chronic Kidney Disease with Artificial Intelligence.” ”.

Antech unveiled RenalTech in October 2019. It is a machine learning-based predictive diagnostic tool for chronic kidney disease in cats that employs algorithms to find patterns in data. Machine learning is a subset of artificial intelligence. Mars PetCare owns both Antech and Banfield. RenalTech was created using data from feline patients who were seen at Banfield Pet Hospitals for 20 years.

The Journal of Veterinary Internal Medicine published details about a version of the model that uses four measurements: age, urine specific gravity, blood urea nitrogen concentration, and creatinine concentration in its November/December 2019 issue. Cats with CKD could be predicted by the model two years before a clinical diagnosis. Dr. Ogeer stated that co-morbidities such as underweight, hepatopathy, diabetes mellitus, and hyperthyroidism were found to be significantly linked to an increased risk of CKD versus no CKD.

White blood cell count, urine protein concentration, and urine pH are additional parameters used by RenalTech. Dr. According to Ogeer, the tool has an accuracy of more than 2095 percent in predicting whether a cat will develop chronic kidney disease (CKD) in the next two years. Antech discovered that, following the completion of approximately 300,000 predictions for cats in the US and Canada, the tool’s median age for cats expected to develop chronic kidney disease (CKD) within the next two years was 15 years, whereas the median age for cats not expected to develop CKD within that time was 9 years.

RenalTech uses measurements from two visits that are more than 60 days apart and take place within 24 months of each other in order to predict a specific cat. Every metric, including a full urinalysis, chemistry profile, and blood cell count, is available.

“Veterinarians can create tailored, targeted care plans for their feline patients with the help of RenalTech’s actionable information,” Dr. Ogeer said.

FAQ

Is gabapentin hard on the kidneys?

Gabapentin doesn’t usually cause kidney problems. But as discussed above, gabapentin may rarely cause DRESS syndrome. Along with the liver, the kidneys may be damaged as a result of DRESS. However, if you have existing kidney problems, they won’t be able to remove gabapentin as well as they should.

What is the best pain relief for cats with kidney disease?

Clinically, NSAIDs can be used to control pain in cats that have CKD, but we are most comfortable using NSAIDs in CKD cats that look relatively healthy with relatively good body condition scores. Once patients begin to lose their appetites, lose weight, and/or look unthrifty, we recommend exercising more caution.

What should cats with kidney disease avoid?

In addition to feeding a lower protein diet, you also need to avoid giving high protein treats such as meat, jerky treats, cheese, rawhides, pig ears, etc. High salt (sodium) diets may increase blood pressure and may worsen kidney damage, so diets designed for pets with kidney disease are low in sodium.

How do you prolong a cat’s life with kidney failure?

Nutrition: A renal diet is a cornerstone of managing CKD and can improve quality of life and prolong patient survival. Enhance the ratio of omega-3 fatty acids to omega-6 fatty acids; restrict protein, phosphorus, and sodium contents; and increase potassium, vitamin, and fiber contents and caloric density.